Analysis of Cell Division and Lineage Tree based on 4D Cell Image Data

Publications

  • Patent: L. Chen, Z. Zhao, and H. Yan, "Method for tracking an object in an image sequence," United States Patent, Number 10,255,692, 2019.
  • J. Cao, G. Guan, V. W. S. Ho, M. K. Wong, L. Y. Chan, C.Tang, Z. Y. Zhao, and H. Yan, "Establishment of morphological atlas of Caenorhabditis elegans embryo using deep-learning-based 4D segmentation," Nature Communications, accepted, 2020.
  • J. Cao, M. K. Wong, Z. Zhao, and H. Yan, "3DMMS: robust 3D membrane morphological segmentation of C. elegans embryo," BMC Bioinformatics, 20:176:1-13, 2019.
  • L. Chen, V. W. S. Ho, M. K. Wong, X. T. Huang, L. Y. Chan, H. C. K. Ng, X. Ren, H. Yan, and Z. Zhao, "Establishment of signaling interactions with cellular resolution for every cell cycle of embryogenesis," Genetics, 209(1):36-49, 2018.
  • X. T. Huang, Y. Zhu, L. H. L. Chan, Z. Zhao, and H. Yan, "Inference of cellular level signaling networks using single-cell gene expression data in Caenorhabditis elegans reveals mechanisms of cell fate specification," Bioinformatics, 33(10):1528-1535, 2017.
  • L. Chen, H. Yan, and Z. Zhao, "A probabilistic relaxation labeling (PRL) based method for C. elegans cell tracking in microscopic image sequences," IEEE Journal of Selected Topics in Signal Processing, 10(1):185-192, 2016.
  • X. T. Huang, Y. Zhu, L. L. H. Chan, Z. Zhao, and H. Yan, "An integrative C. elegans protein-protein interaction network with reliability assessment based on a probabilistic graphical model," Molecular BioSystems, 12:85-92, 2016.
  • V. W. S. Ho, M. K. Wong, X. An, D. Guan, J. Shao, K. He, J. Liao, L. Chen, X. Huang, Y. Xia, L. L. H. Chan, K. L. Chow, H. Yan, and Z. Zhao, "Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry," Molecular Systems Biology, 11:814:1-18., 2015.
  • L. Chen, L. L. H. Chan, Z. Zhao, and H. Yan, "A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images," BMC Bioinformatics, 14:328, 2013.